Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age

R Zeng; CJ Lodge; JJ Koplin; DJ Lopez; B Erbas; MJ Abramson; D Eyles; AL Ponsonby; M Wjst; K Allen; SC Dharmage; AJ Lowe

Journal article

Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age

R Zeng, CJ Lodge, JJ Koplin, DJ Lopez, B Erbas, MJ Abramson, D Eyles, AL Ponsonby, M Wjst, K Allen, SC Dharmage, AJ Lowe

Nutrients | MDPI | Published : 2024

DOI: 10.3390/nu16091303

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Abstract

BACKGROUND: Early-life vitamin D is a potentially modifiable risk factor for the development of eczema, but there is a lack of data on longitudinal associations. METHOD: We measured 25(OH)D3 levels from neonatal dried blood spots in 223 high-allergy-risk children. Latent class analysis was used to define longitudinal eczema phenotype up to 25 years (4 subclasses). Skin prick tests (SPTs) to 6 allergens and eczema outcomes at 6 time points were used to define eczema/sensitization phenotypes. Associations between 25(OH)D3 and prevalent eczema and eczema phenotypes were assessed using logistic regression models. RESULTS: Median 25(OH)D3 level was 32.5 nmol/L (P25-P75 = 23.1 nmol/L). Each 10 nmo..

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University of Melbourne Researchers

Caroline Lodge Author

Bircan Erbas Author

Anne-Louise Ponsonby Author

Shyamali Dharmage Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

R.Z. is supported by the Australian Commonwealth Government and the University of Melbourne PhD scholarship. S.C.D. (APP1193993), A.J.L. (1145096), C.J.L. (2008019), A.-L.P. (1110200) and J.J.K. (1158699) are supported by a National Health and Medical Research Council (NHMRC) fellowship. We acknowledge the work of all the investigators and staff in the MACS cohort. We thank all the MACS families for their participation and ongoing support for this study.